2022년 06월 27일 (월) 오후 4시

연사: 가톨릭대학교 의대 해부학교실 김인범 교수님

제목: Stunning Relationship between Anatomy and Physiology in Retinal Circuit Organization: Lessons from Non-image-forming Photoreception Processing 

초록: For hundred years or more It has been known that rods and cones are the only photoreceptive cells in the retina. The light signals generated in these photoreceptors, after processing by downstream retinal neurons (bipolar, horizontal, amacrine and ganglion cells), are transmitted to the brain via the axons of the ganglion cells for further analysis. Bipolar cells are the second order neurons of the retina. They relay visual signals from photoreceptors to the ganglion cells which are the projection neuron of the retina. Based on their morphology, there are ≈10 types of cone bipolar cells and one type of rod bipolar cells. These bipolar cells are divided ON and OFF cells according to the light response polarity. The OFF bipolar cell axons ramify in sublamina a (OFF sublamina) in the inner plexiform layer (IPL), where the proximal half synapses onto dendrites of ganglion and amacrine cells showing OFF response, while ON bipolar axons stratify in sublamina b (ON sublamina), where the distal half makes synapses onto dendrites of ganglion cells and amacrine cells showing ON response. This stunning relationship between anatomy and physiology is the fundamental principle of retinal circuit organization.