부산대학교 전자공학과 엄경식 교수님: Recent Advancements in High-Resolution Photonic R…
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작성자 관리자 댓글 조회 작성일 22-11-28 23:44본문
2022년 11월 28일 (월) 오후 4시
연사: 부산대학교 전자공학과 엄경식 교수님
제목: Recent Advancements in High-Resolution Photonic Retinal Prostheses
초록: Retinitis pigmentosa, age-related macular degeneration, and Stargardt disease are the most common incurable eye diseases associated with outer retinal degeneration leading to blindness. Among the various current trials to cure those diseases including optogenetic stimulation and stem cell therapy, only electrical retinal prosthetics have validated clinical promise. Since most retinal ganglion cells (RGCs) in those diseases remain intact, the cells can convey visual signals to the brain when properly stimulated as in the electrical retinal prosthetics. Yet, electrical prosthetics still suffer from fundamental limitations such as the invasive nature of the device and both the limited number and fixed location of stimulation sites. Here, this study establishes the feasibility of a novel, minimally invasive, high-resolution retinal prosthetics in animal models, based on an emerging neuromodulation approach, nanoparticle-enhanced near-infrared neural stimulation. When a neuron is attached to gold nanorods (AuNRs), near-infrared (NIR) light illumination with a wavelength matching the nanorod’s resonant wavelength was shown to activate the neuron via photothermal effects. Moreover, photovoltaic retinal prostheses have also been developed by using a bidirectional photodiode. In this talk, I will present in-vitro and in-vivo results of plasmonic retinal prostheses and in-vitro results of bidirectional photodiode retinal prostheses.
연사: 부산대학교 전자공학과 엄경식 교수님
제목: Recent Advancements in High-Resolution Photonic Retinal Prostheses
초록: Retinitis pigmentosa, age-related macular degeneration, and Stargardt disease are the most common incurable eye diseases associated with outer retinal degeneration leading to blindness. Among the various current trials to cure those diseases including optogenetic stimulation and stem cell therapy, only electrical retinal prosthetics have validated clinical promise. Since most retinal ganglion cells (RGCs) in those diseases remain intact, the cells can convey visual signals to the brain when properly stimulated as in the electrical retinal prosthetics. Yet, electrical prosthetics still suffer from fundamental limitations such as the invasive nature of the device and both the limited number and fixed location of stimulation sites. Here, this study establishes the feasibility of a novel, minimally invasive, high-resolution retinal prosthetics in animal models, based on an emerging neuromodulation approach, nanoparticle-enhanced near-infrared neural stimulation. When a neuron is attached to gold nanorods (AuNRs), near-infrared (NIR) light illumination with a wavelength matching the nanorod’s resonant wavelength was shown to activate the neuron via photothermal effects. Moreover, photovoltaic retinal prostheses have also been developed by using a bidirectional photodiode. In this talk, I will present in-vitro and in-vivo results of plasmonic retinal prostheses and in-vitro results of bidirectional photodiode retinal prostheses.
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